Upregulation of the intracellular iron-storage protein ferritin light chain has been reported in AD, and studies have shown that the ferritin positivity is specifically associated with microglia (Connor et al., 1992;Grundke-Iqbal et al., 1990), particularly microglia in dystrophic states (Lopes et al., 2008). The gene discussed is FTL; the disease is Alzheimer disease.