Compared to healthy controls, a significantly higher FC was observed between the inferior and superior longitudinal fasciculus FNs in myotonic dystrophy patients (J. Li et al., 2022).Lin et al. (2021)demonstrated in their study that the mild cognitive impairment (MCI) APOE4 carriers showed decreased FC at the right temporopolaris, left corticospinal tract, and bilateral posterior limb of the internal capsule compared to MCI patients who did not have the APOE4 gene. Here, APOE is linked to Cognitive impairment.