The medial temporal compositehad the highest Youden index across all diagnostic classifications, indicating that thiscomposite was sensitive to the earliest clinically-relevant tau accumulations in this sample.The high specificity of tau in this region suggests that here: 1) the presence of tau is notoverestimated and 2) the presence of tau is a good indicator of cognitive impairment. This evidence concerns the gene MAPT and Cognitive impairment.