Regarding in vivo AD models, we have published that BHB dosed as KD or BHB itself reverses memory deficits in two in vivo mouse models of AD, PS1/APP (Di Lucente et al., 2024a) and 5XFAD (Di Lucente et al., 2024b), and our preliminary data in ApoE4 mice show something similar. The gene discussed is APP; the disease is Alzheimer disease.