ALDH7A1 and pyridoxine-dependent epilepsy: Pyridoxine-dependent epilepsy (PDE, OMIM code: #266100), also identified as pyridoxine-dependent developmental and epileptic encephalopathy, is a rare neurometabolic disease inherited from biallelic deleterious mutations in ALDH7A1 gene, situated at the 5q32.3 locus [1].