Hv1 activity during microglial activation exacerbates neuroinflammation into the injured/aberrant microenvironment during ischemic stroke (Wu et al., 2012), traumatic brain injury (Ritzel et al., 2021), spinal cord injury (Li et al., 2021), chronic pain (Zhang et al., 2022) and neurodegenerative conditions such as multiple sclerosis (Chen et al., 2020) and Parkinson’s disease (Neal et al., 2023). Here, HVCN1 is linked to ischemic stroke.