Past work has demonstrated a relationship between pathologic burden and GM structure in FTLD-tau (Burke et al., 2022;Giannini, Xie, McMillan, et al., 2019;Irwin et al., 2016,2018), and the existence of an interrelationship between brain function and brain structure is well established (Chappell et al., 2021;Du et al., 2006;Meltzer et al., 1990;Olm et al., 2016;Tosun et al., 2012) so atrophy and partial volume effects (PVE) may influence the demonstrated CBF-pathologic burden relationship. This evidence concerns the gene MAPT and Atrophy.