Importantly, focal tau PET signal among CU has been critical in understanding rates of future progression to mild cognitive impairment and/or dementia (Cai et al., 2023;Ossenkoppele, Pichet Binette, et al., 2022), as well as in explaining subtle differences in memory (Lowe et al., 2019;Maass et al., 2019;Sperling et al., 2019). The gene discussed is MAPT; the disease is dementia.