Numerous [18F]MK-6240 PET studies have reportedstrong signal-to-noise ratio in tau-bearing areas, showing utility for the detectionof early and late accumulation of tau, as well as for disease staging in individualsranging from preclinical to symptomatic AD (Bennacefet al., 2017;Betthauser, Koscik, et al.,2019;Pascoal et al., 2020a,2020b). The gene discussed is MAPT; the disease is Alzheimer disease.