Germline pathogenic mutations in TP53 cause Li-Fraumeni syndrome, a rare autosomal dominant disorder characterized by a markedly increased predisposition to malignancies across a broad spectrum of tumor types.102 Among women diagnosed as having breast cancer before the age of 31, 3.8 – 7.7% carry disease-causing germline TP53 mutations. This evidence concerns the gene TP53 and Li-Fraumeni syndrome.