BRCA2 and breast cancer: Women with biopsy-confirmed lobular carcinoma in situ, atypical ductal hyperplasia, ductal carcinoma in situ, or invasive breast cancer should undergo annual MAM or MRI screening following diagnosis.120 For those with a family history of breast cancer, annual MAM or MRI screening should begin 10 years before the age at diagnosis of the youngest affected relative, but not before the age of 30.122 Women with BRCA1 or BRCA2 mutations should start annual MAM or MRI screening at 25 – 30 years old.