Therefore, this study aimed to bridge the gap between periodontal and obstetric research by (1) evaluating the association between first-trimester gingival crevicular fluid PlGF/sFlt-1 ratios and the risk of sPTB, and (2) exploring the relationship between angiogenic markers in the GCF and periodontal disease severity during pregnancy. This evidence concerns the gene SPTB and periodontal disorder.