The small molecule inhibitors FR-900359 (FR) and YM-254890 (YM) have been shown to effectively inhibit wild-type and mutant Gαq/Gα11/Gα14 proteins and downstream signaling, resulting in either UVM cell death in vitro or slowed tumor growth in vivo.16,30,31,32,33,34 Unfortunately, FR and YM cannot discriminate between the wild-type and mutant versions of Gαq/Gα11, which is prohibitively toxic for systemic delivery.35 The gene discussed is GNA11; the disease is neoplasm.