Prolonged activated partial thromboplastin time (aPTT) and reduced activity of factor VIII (20.2%), von Willebrand factor (23.2%), and von Willebrand factor antigen (31.3%), as well as platelet hypofunction on aggregometry, led to a diagnosis of type 1 von Willebrand disease being made. The gene discussed is VWF; the disease is Von Willebrand disease.