Although the one positive MDM2 FISH result among our 43 cases may not be statistically significant, the value of MDM2 FISH testing in morphologically atypical spermatic cord lipomas becomes more accentuated when comparing the minor FISH testing costs to the major costs of misdiagnosis leading to surgical re-operation or even delayed patient presentation with metastasis given that evaluation for MDM2 gene amplification status is of therapeutic importance as amplified neoplasms are amenable to targeted therapy [12], and the patient would have missed the opportunity of targeted treatment. This evidence concerns the gene MDM2 and neoplasm.