In lipomas of the spermatic cord, the presence of fibrous septa containing atypical cells with enlarged hyperchromatic nuclei can mimic a well-differentiated liposarcoma, and MDM2 gene amplification by FISH can be a cost-effective and efficient method in such cases to avoid missing a well-differentiated liposarcoma of the spermatic cord. This evidence concerns the gene MDM2 and liposarcoma.