For example, angiopoietin-line protein 2 (ANGPTL2) in EAT was shown to positively correlate with atrial fibrosis in AF patients[123], while pharmacological inhibition of Angptl2 significantly reduced fibrotic gene expression in primary rat cardiac fibroblasts and ameliorated induced fibrosis in organo-cultured rat atria [Figure 4][124]. The gene discussed is ANGPTL2; the disease is atrial fibrillation.