EZH2 and atrial fibrillation: Their study showed decreased production of methyltransferase Ezh2 in the atria of aged mice with AF [Figure 6] and unveiled that Ezh2 restored H3K27me3 levels in the promoter regions of CDKN2a and Timp4 genes in primary mouse atrial fibroblasts at late passages, preventing senescence development and alleviating profibrotic effects[156].