Furthermore, β-adrenergic regulation of the cardiac Na/K-ATPase mediated by oxidative signaling (Galougahi et al., 2012), and Src represents a key intermediate and novel therapeutic target in the pathophysiology of cerebral ischemia, where it appears to regulate neuronal damage by influencing VEGF-mediated vascular permeability (Paul et al., 2001). The gene discussed is SRC; the disease is brain ischemia.