Cinobufagin significantly inhibited the growth of Skov3 ovarian cancer cells, triple-negative breast cancer metastasis, by regulating the Forkhead Box S1 (FOXS1) gene, the CCL2/CCR2 signaling, and FAK/STAT3 signaling (Dai et al., 2023; Zhu et al., 2024; Wang et al., 2025). The gene discussed is FOXS1; the disease is ovarian carcinoma.