Elevated plasma CTS has been observed in patients with hypertension, CVD, CKD, CKD-related cardiomyopathy, and congestive HF, in which different Na/K-ATPase signaling functions were involved (Kelly and Smith, 1993; Bagrov et al., 1998; Kiselyov et al., 1999; Kaplan, 2002; Komiyama et al., 2005; Liu, 2005; Kolmakova et al., 2011; Bai et al., 2013; Pavlovic, 2014; Kennedy et al., 2015; Pavlovic, 2020). This evidence concerns the gene TTR and chronic kidney disease.