BCL2L11 and cancer: Moreover, resisting cell death is one of the iconic hallmarks of cancer reviewed by Hanahan and Weinberg, alternatively by up-regulating the expression of anti-apoptotic regulators such as BCL-2 and BCL-XL while down-regulating pro-apoptotic factors such as Bax, Bim, and Puma (Hanahan and Weinberg 2011).