We also found that genetic factors such as the APOE ε4 allele and biomarkers forAlzheimer’s disease pathology (amyloid-beta) and chronic inflammation (YKL-40) appearto be promising modifiers of within-person WM changes (Racineet al., 2019; Song et al., 2018), especially inthe fornix, a WM region susceptible to aging and neurodegeneration (Lacalle-Aurioles & Iturria-Medina, 2023). This evidence concerns the gene APOE and glycogen storage disease VI.