Through comparative analysis with hypoxia-related genes, we identified 9 HRDEGs, specifically RCOR2, STAT3, NOTCH1, SP1, SART1, PRIM1, LYAR, KIF20B, and MSH2, which may play pivotal roles in the etiology of IDD. This evidence concerns the gene PRIM1 and intervertebral disk degenerative disorder.