Notably, CIBERSORT analysis of immune cell infiltration demonstrated a predominance of neutrophils in IDD samples, which were significantly correlated with specific hypoxia-related genes (e.g., NOTCH1, SP1, and STAT3), suggesting a substantial role for neutrophils in the inflammatory immune microenvironment associated with IDD. This evidence concerns the gene STAT3 and intervertebral disk degenerative disorder.