Through comparative analysis with hypoxia-related genes, we identified 9 HRDEGs, specifically RCOR2, STAT3, NOTCH1, SP1, SART1, PRIM1, LYAR, KIF20B, and MSH2, which may play pivotal roles in the etiology of IDD. The gene discussed is SART1; the disease is intervertebral disk degenerative disorder.