The results showed that the genes KIF20B (AUC = 0.803, Figure 3C), LYAR (AUC = 0.779, Figure 3D), NOTCH1 (AUC = 0.762, Figure 3E), PRIM1 (AUC = 0.798, Figure 3F), SART1 (AUC = 0.773, Figure 3G), SP1 (AUC = 0.789, Figure 3H), RCOR2 (AUC = 0.805, Figure 3I), STAT3 (AUC = 0.774, Figure 3J) and MSH2 (AUC = 0.822, Figure 3K) expression had certain accuracy in the diagnosis of the occurrence of disc degeneration. This evidence concerns the gene PRIM1 and intervertebral disk degenerative disorder.