The results showed that RCOR2, STAT3, and NOTCH1 expression levels were significantly more effective for diagnosing intervertebral disc degeneration than other variables, while the utility of SP1, SART1, PRIM1, LYAR, KIF20B, and MSH2 expression in diagnosing intervertebral disc degeneration was lower. Here, LYAR is linked to Intervertebral disk degeneration.