For the treatment of Cryo-GN associated with lymphoproliferative disorders, chemotherapy was adopted for hematopoietic malignancies that producing cryoglobulin or non-malignant proliferative MGRS: the plasma cell derived (monoclonal IgG) were treated with anti-plasma cell drugs such as bortezomib, and/or thalidomide, lenalidomide; lymphoplasmacytoid cell lymphoma can produce monoclonal IgM and often take the rituximab(RTX)-containing treatments (46). Here, CD40LG is linked to lymphoproliferative syndrome.