CD8A and graft versus host disease: We have previously reported that the treatment of mice with poly(lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) decorated with anti-CD2 antibodies and encapsulating IL-2 and TGF-β induced tolerogenic CD4+ and CD8+ pTregs that protected mice from fatal graft-versus-host disease (GvHD).