To further dissect the immunoregulatory role of TIGIT in the tumor microenvironment, we analyzed scRNA-seq data from CRC patients (GSE178341), analysis revealed that TIGIT expression was predominantly localized to TNKILCC cells, a T cell population enriched in exhausted and cytotoxic features (Figure 5A) (36). The gene discussed is TIGIT; the disease is colorectal carcinoma.