NECTIN2 and colorectal carcinoma: Using ScRNA seq data (GSE146771) of CRC pre-clinical model, we found that NECTIN-2 and PVR, the two primary ligands of TIGIT, are predominantly expressed by stromal cells, especially endothelial and fibroblast populations (16, 20, 23), particularly endothelial and fibroblast cells (Figures 2A, B).