TIGIT is known to exert its immunosuppressive effects via binding to its ligands, PVR (CD155) and NECTIN-2 (CD112), which are commonly expressed on antigen-presenting cells and tumor cells, thereby attenuating cytotoxic T cell responses (16).Cell–cell interaction (CCI) analysis revealed extensive crosstalk between CD8+ Tex cells and other immune populations, including dendritic cells, neutrophils, and Tregs (Figures 1D, E). Here, CD8A is linked to neoplasm.