In a murine model with experimental autoimmune uveitis, miR-223 drives macrophages toward an anti-inflammatory (M2) phenotype by suppressing NLRP3/Notch signaling (32)—a mechanism confirmed in human IBD, where reduced miR-223 in inflamed tissues correlates with elevated IL-6 and TNF-α (33). The gene discussed is IL6; the disease is inflammatory bowel disease.