This lower level of sHLA-G, particularly in comparison to healthy populations, is consistent with findings in other autoimmune diseases such as systemic sclerosis (SSc), rheumatoid arthritis, juvenile idiopathic arthritis, and systemic lupus erythematosus, suggest that low sHLA-G expression correlates with high disease activity (55). This evidence concerns the gene HLA-G and rheumatoid arthritis.