Previously, our group has shown that Th1* (CCR6+, CXCR3+, CCR4−)cells exhibit a hybrid Th1/Th17 lineage signature along with a distinct transcriptional profile marked by genes linked to TB susceptibility, heightened T cell activation, increased survival, and cytotoxic functions resembling those of CTLs (8). This evidence concerns the gene CCR6 and tuberculosis.