A study demonstrated that Th1 cells are the dominant T helper subset in tuberculosis, appearing as low-differentiated CXCR3+CCR6+ cells in the blood and transitioning into highly differentiated CXCR3+/−CCR6− cells in the lungs, highlighting their key role in TB immunity and the compartment-specific maturation of antigen-specific T cells (48). Here, CCR6 is linked to tuberculosis.