STXBP1 and Alzheimer disease: Proteomics analysis (Fig. 4e; Table S18) showed Resilient had elevated synaptic proteins (SNAP25, STX1A, STX1B, STXBP1, SYT12, and VGF), previously implicated in synaptic maintenance in AD (Ramos-Miguel et al., 2021; Yu et al., 2023).