Compared to other subtypes, Resilient and Late-Onset Decline exhibited lower levels of β-amyloid deposition, tau tangle density, TDP-43, and cerebral amyloid angiopathy (CAA), alongside slower cognitive decline and higher residual cognition (De Jager et al., 2018; Yu et al., 2015) and Mini-Mental State Examination (MMSE) scores (Trzepacz et al., 2015). This evidence concerns the gene TARDBP and Mental deterioration.