In detail, in Sirt3 knockout mice, there is increased mtDNA damage and cardiac hypertrophy, whereas SIRT3 overexpression protects mtDNA through maintaining levels of oxoguanine-DNA glycosylase-1 (OGG1), a key enzyme that repairs mtDNA damage, thus highlighting SIRT3’s crucial role in safeguarding mitochondrial integrity under Doxo treatment [93]. The gene discussed is SIRT3; the disease is cardiac hypertrophy.