In addition, curcumin, known for its neuroprotective properties, has been shown to attenuate Aβ-induced neuronal metabolic dysfunction and improve cognitive function in an AD mouse model by upregulating SIRT3, indicating that SIRT3 plays a neuroprotective role in AD, potentially by modulating Aβ-related pathways [161]. This evidence concerns the gene SIRT3 and Alzheimer disease.