In Alzheimer’s disease models, aerobic exercise improved irregular autophagy by reducing mTOR expression (Almeida et al., 2018; Fucà et al., 2017; Jang et al., 2018a; Mejías-Peña et al., 2016; Mejías-Peña et al., 2017; Yuan et al., 2018; Zhao et al., 2018; Table 3). This evidence concerns the gene MTOR and early-onset autosomal dominant Alzheimer disease.