Our findings align with a prior investigation in which low axial skeletal muscle mass, as measured by magnetic resonance imaging, was independently associated with higher NT-proBNP among 205 outpatients with HFrEF or HF with preserved ejection fraction, with a coefficient of −0.305 (standard error 0.051, p-value 0.0001).9 The gene discussed is NPPB; the disease is hydrops fetalis.