PANK1 and pantothenate kinase-associated neurodegeneration: Pantothenate-kinase-associated neurodegeneration (PKAN) is a rare, autosomal recessive neurological disorder characterized by the progressive degeneration in the globus pallidus and surrounding regions of the central nervous system.1-3 PKAN is the most common form of neurodegeneration associated with brain iron accumulation (NBIA), a group of clinical disorders characterized by abnormal involuntary movements, alterations in muscle tone, and extrapyramidal signs.