Pinnipeds have also shown human-like vascular Aβ deposits colocalized with APOE in the arterial and capillary walls.16 The eldest sea lions (aged 27–32 years) showed more severe cerebral amyloid angiopathy pathology compared to the younger pinnipeds and followed a similar regional progression in the frontal, temporal, parietal and occipital lobes16 as humans with dementia.46 Although the findings of this report seem promising, it was the first study to report spontaneous Alzheimer's disease-like pathology in aged pinnipeds and further investigation is required. This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.