In lung cancer, methylated YBX1 interacts with the tumor suppressor hY4F to mediate the selective sorting and secretion of hY4 RNA fragments into extracellular vesicles, leading to up-regulation of MAPK/NF-κB signaling pathway activity and promoting the proliferation, migration, and invasion of lung cancer cells (20). The gene discussed is NFKB1; the disease is lung cancer.