Lastly, in T-cell acute lymphoblastic leukemia (T-ALL), downregulation of YBX1 results in inhibition of total AKT, p-AKT, total extracellular signal-regulated kinase (ERK), and p-ERK expression, playing a pivotal role in the development of T-ALL (30). This evidence concerns the gene AKT1 and acute lymphoblastic leukemia.