HERC5 and triple-negative breast carcinoma: In triple-negative breast cancer, YBX1 in the cytoplasm directly binds to SAT1 protein, and the mTOR mRNA accumulated through YBX1 protein-mediated methyl-5-cytosine (m5C) modification is stabilized through E3 ligase HERC5-mediated deubiquitylation, which significantly inhibits autophagy and accelerates tumor progression in triple-negative breast cancer (26).