Prespecified subgroups were stratified by sex, ECOG PS score, Child-Pugh class, BCLC stage, hepatitis status, cirrhosis, tumor focality (solitary/multiple), maximum diameter, portal vein invasion, VP-classified tumor thrombosis, extrahepatic metastasis, Albumin-Bilirubin (ALBI) score, AFP level, age, and BMI. This evidence concerns the gene AFP and Hepatitis.