Our results showed that Gal3 levels in the blood and kidneys of patients increased gradually with the progression of diabetes or DKD and were significantly correlated with renal fibrosis (Figure 1), which is consistent with previous studies.[12] Gal3 has been reported to function as an advanced glycation end‐products (AGEs) receptor (RAGE), facilitating the clearance of excessive AGEs in glomeruli during diabetic glomerulopathy. This evidence concerns the gene LGALS3 and diabetes mellitus.