In mice, ablation of Gal3 leads to AGEs accumulation and accelerates diabetic glomerulopathy.[33] Conversely, subsequent studies have shown that Gal3 knockout promotes diabetic retinal angiogenesis and inhibits the development of diabetic retinopathy by improving blood‐retinal barrier dysfunction in diabetic patients.[34, 35] These studies indicate the complex role of Gal3 in diabetic complications. Here, LGALS3 is linked to diabetic retinopathy.