LGALS3 and immune system disorder: Gal3 is widely expressed in tissues and cells, especially in activated macrophages.[28, 36] During DKD, immune disorder and inflammation are increased, with macrophages showing an elevation exceeding 50%.[37, 38, 39, 40, 41] Conditional depletion of macrophages in diabetic mice substantially mitigated kidney injury, and chimeric experiments indicated that most macrophages originated from the bone marrow.[40] Nevertheless, the mechanisms by which macrophages contribute to DKD remain elusive.