Besides DKD, Gal3 also participates in the development of various acute and chronic kidney diseases.[17, 18, 19] Given the dual functions of RAGE (mediating extracellular AGEs clearance and facilitating their entry into cells, causing stress) and the limited impact of AGEs on CKD, Gal3 may exert additional effects on DKD and CKD. The gene discussed is LGALS3; the disease is diabetic kidney disease.