Notably, Gal3 has been shown to modulate inflammatory signaling in various diseases, such as atherosclerosis, pulmonary disorders, and nonalcoholic steatohepatitis.[42, 43] In our study, Gal3 knockout also alleviated kidney inflammation in DKD mice (Figures S2d, g, S3d, and S6g, Supporting Information), suggesting a potential association between Gal3 and inflammation in DKD progression. Here, LGALS3 is linked to lung disorder.