Renal fibrosis is a major consequence of DKD patients, yet effective treatments remain limited.[32] Our previous studies showed that Gal3 is associated with insulin resistance and islet β‐cell dysfunction in obesity and diabetes.[28, 29] Gal3 is also implicated in various inflammatory and fibrotic diseases; however, its direct involvement in the pathogenesis of renal fibrosis and DKD has remained elusive. Here, LGALS3 is linked to obesity disorder.