TNFRSF11B and autoimmune disease: B lymphocytes exert dual roles by producing osteoprotegerin (OPG), a decoy receptor that inhibits RANKL‐induced osteoclast differentiation, and autoantibodies that may paradoxically exacerbate bone loss in autoimmune disorders.[29] Although neutrophils are essential for early‐stage pathogen clearance, their overproduction of reactive oxygen species (ROS) in chronic conditions such as diabetic bone defects perpetuates oxidative stress, impairing vascularization and delaying healing.