Our experimental results further revealed that upregulation of DYNC1H1 resulted in a significant increase in the number of proliferating and invading NSCLC cells, whereas downregulation of DYNC1H1 resulted in the opposite trend, suggesting that DYNC1H1 might be an oncogene in the tumor microenvironment. This evidence concerns the gene DYNC1H1 and non-small cell lung carcinoma.