Among the symptoms of AD, sleep-related issues are highly prevalent, affecting up to 60% of patients.[4] Symptoms such as prolonged sleep latency, frequent awakenings, decreased total sleep time (TST), and impaired sleep efficiency often appear early and worsen as the disease progresses.[5] Disruptions in circadian rhythms, such as a reversal of the sleep-wake cycle, are also common, likely due to the impact of AD pathology on the suprachiasmatic nucleus (SCN), the brain’s “master clock.”[6] This disruption weakens circadian signals, resulting in irregular sleep-wake patterns. Here, CLOCK is linked to Alzheimer disease.