KL and systemic lupus erythematosus: Some studies have investigated the relationship between Klotho and certain AIDs, finding no association between Klotho and MS,[42,43] as well as no association between Klotho and SLE.[44] However, it has been found that Klotho is significantly decreased in T1D patients and may be related to other factors such as the kidneys.[45] The relationship between Klotho and other AIDs remains unclear.