CRP and aortic stenosis: Furthermore, evidence did not suggest reverse causation, implying that CVD does not affect CRP levels.[17] Brian A. Ference and colleagues presented strong evidence indicating that LDL is not merely a risk marker but a causal factor in the development of Atherosclerotic Cardiovascular Disease.[18] Susanna C. Larsson and her team conducted MR studies, identifying a significant relationship between a higher BMI, especially fat mass index, and an increased risk of aortic stenosis and other cardiovascular diseases.[19]