ENO2 and Spinocerebellar ataxia type 3: Some researchers even believe that neuronal damage may precede the onset of clinical symptoms.[8] Previous studies have shown that the serum NSE concentration of SCA3 patients is significantly higher than that of the normal control group and is positively correlated with the disease course and ICARS score, indicating that the longer the disease course of SCA3, the higher the serum NSE level of patients with more severe conditions.