Studies have shown that T1 to 11 and JMF1907 alleviate pontine neuronal death, cerebellar transcriptional inhibition, and ataxia symptoms in SCA3 transgenic mice induced by mutated ataxia protein-3-Q79 by enhancing proteasome activity and reducing the protein levels of polyglutamine-amplified ataxia-3-Q79 in the pons and cerebellum. Here, ATXN3 is linked to Ataxia.