CD24 and Sepsis: Disruption of this anti-inflammatory “braking” mechanism, such as through the presence of CD24 antibodies, can lead to a cytokine storm.[72–78] The absence of CD24 and IgD expression on B cells may contribute to immune evasion and the occurrence of cytokine storms in patients with sepsis, potentially explaining our finding that IgD − CD24 − B cells are associated with an increased risk of sepsis.