Among the 3 identified functional receptors, the BAFF receptor (BAFF-R) is primarily responsible for B cell survival and differentiation.[60] Studies have demonstrated that BAFF-mediated stimulation can inhibit apoptosis induced by signals through CD20 and B-cell receptors (BCR), thereby enhancing B cell survival.[61] Our study is consistent with the findings of Saito et al, suggesting that BAFF-R on CD20 − B cells may play a protective role against sepsis by mediating B cell survival and bolstering the immune system’s resistance to foreign pathogens. The gene discussed is TNFSF13B; the disease is Sepsis.