PROS1 and neoplasm: Figures 7A, 8A, and 9A show that stage I (American Joint Committee on Cancer 8th, AJCC 8th) PTC patients with no recurrence typically had intense PROS1, CLU, and LRG1 staining, whereas PTC patients with tumor recurrence after primary surgical treatment typically had low or moderate staining (Figs. 7B, 8B, and 9B).