PROS1 gene expression was found to be higher in PTC samples than in healthy thyroid tissue, according to Wang et al. Although the PROS1 gene expression was statistically unrelated to the patient’s age, gender, tumor classification, extrathyroidal invasion, and BRAFV600E mutation, it was strongly correlated with the classification of lymph nodes.[19] In Wang et al’s study, with no patients at stages III and IV and only a few patients at stage II, our study may produce results that are incongruent. This evidence concerns the gene PROS1 and neoplasm.