We observed a high frequency of events (such as diarrhea, nausea, vomiting, stomatitis, decreased appetite, rash, palmar-plantar erythrodysesthesia syndrome, skin toxicity, hepatotoxicity [markedly elevated ALT or AST, jaundice], anemia, and peripheral neuropathy) within the gastrointestinal, skin and subcutaneous tissue, metabolic and nutritional, hepatobiliary, and nervous system categories. The gene discussed is GPT; the disease is peripheral neuropathy.