SLC6A3 and Alzheimer disease: Recent studies have demonstrated that dopamine transporter (DAT) imaging using Single-Photon Emission Computed Tomography (SPECT) (e.g., 123I-FP-CIT) shows high diagnostic sensitivity (78%-93%) and specificity (84%-90%) for DLB, particularly in distinguishing it from AD, though its accuracy can be influenced by factors such as medication use, patient movement, and image processing, thus it should be used in conjunction with other diagnostic tools and clinical assessments to enhance diagnostic confidence [59–61].