Additionally, HRi tumors demonstrated DEGs of kinase pathways including PI3K/AKT signaling in cancer (FE = 11.5, FDR = 8.88 × 10−3), ALK (FE = 22.7, P = 0.0276), and NTRK1 (FE = 8.1, P = 0.0330). This evidence concerns the gene AKT1 and cancer.