The reasonable mechanism for the relationship between alcohol consumption and psoriasis involves chronic systemic inflammation in individuals who consume alcohol, leading to an increase in inflammatory cytokines associated with psoriasis (interleukin [IL] 1 β, IL-6, IL-8, IL-12, IL-17, and IL-23, as well as interferon-γ, tumor necrosis factor [TNF]-α)[25]. This evidence concerns the gene TNF and psoriasis.