The effectiveness of [68Ga]Ga-NOTA-C25 PET imaging in detecting STING agonist/anti-PD-1 mAb induced upregulation of LAG-3+ TILs was assessed in a murine HCC model at early (day 4) and late (day 13) time points (Fig. 2A). The gene discussed is LAG3; the disease is hepatocellular carcinoma.