LAG3 and neoplasm: In a previous study, the targeted LAG-3 PET probe [68Ga]Ga-NOTA-C25, developed from a low-molecular-weight cyclic peptide (CVPMTYRAC), demonstrated high molar activity, excellent in vitro stability, and hydrophilicity, showing strong potential for accurately detecting LAG-3 expression in tumor-infiltrating lymphocytes (TILs) and evaluating the therapeutic efficacy of ICIs [23, 24].