To ectopically express COUP-TFII in tumor capillary BECs, we established a mouse model that drives inducible expression of COUP-TFII specifically in ECs, by crossing the VECadherin-CreERT2 strain32 with the Rosa26LoxP-Stop-LoxP(LSL)-COUP-TFII mice33 (termed iCoup mice hereafter). Here, NR2F2 is linked to neoplasm.