CD4 and neoplasm: Given the observation that ectopic COUP-TFII upregulated the expression of CXCL10 in tumor ECs in a cell-autonomous manner (Fig. 3H), we hypothesized that this chemokine selectively promoted T cell recruitment: CXCL10 is well established for its role in mediating T cell recruitment through its receptor CXCR3, which is predominantly expressed on activated CD8 + T cells and Th1-differentiated CD4 + T cells36.