Towards that end, we generated heterozygous Rosa26LSL-iCOUP x Rosa26LSL-tdTomato inducible reporter mice driven by Cdh5-CreERT2, implanted PyMT or KPC tumors orthotopically, and then treated tumor-bearing mice with limiting doses of tamoxifen (Fig. 3A). The gene discussed is CDH5; the disease is neoplasm.