The protein levels of cleaved caspase-3 and Bax were decreased, and those of Bcl-2 were increased in the 8KR group, indicating that inhibition of Drp1 SUMOylation prevented MAPL-induced NPC apoptosis (Fig. 4b, c and Fig. S9B–I). This evidence concerns the gene DNM1L and nasopharyngeal carcinoma.