VCL and osteoporosis: As an initial attempt to explore the potential involvement of alteration in expression of FA protein vinculin in the pathogenesis of osteoporosis, human bone tissue samples were collected from young (from 29 to 32 years old) and aged individuals (from 78 to 88 years old) and subjected to immunofluorescence (IF) staining of these bone sections to determine the expression level of vinculin protein.